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The Future of Diabetes Care: Encapsulation Strategies for Beta Cell Therapy

PhD defence, Thursday 22 February 2024, Mette Steen Toftdal

Mette Steen Toftdal

During her PhD studies, Mette Steen Toftdal explored the encapsulation of beta cells in biomaterials. By transplanting insulin-secreting beta cells into patients with type 1 diabetes, it may be possible to cure the disease entirely. Encapsulation of beta cells into protective biomaterial environments can increase their survival and therapeutic effect. Mette Steen Toftdal studied the survival and function of encapsulated beta cells and improved the biomaterial environment to yield better cell survival.

This research contributes to the ongoing pursuit of finding a cure for type 1 diabetes and offers new avenues for the development of biomaterial-based approaches for diabetes therapy.

The PhD study was completed at Biological and Chemical Engineering, Faculty of Technical Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Thursday, 22 February 2024 at 13.00
Place: Building 3130, room 303, Gustav Wieds Vej 10C, 8000 Aarhus C
Title of PhD thesis: Mechanically reinforced beta cell encapsulation device with drug delivery functions.

Contact information: Mette Steen Toftdal, e-mail: mettetoftdal@bce.au.dk

Members of the assessment committee:

Professor Junbai Li, Institute of Chemistry, Chinese Academy of Sciences, China

Professor Nils Billestrup, Department of Biomedical Sciences, University of Copenhagen, Denmark

Associate Professor Edzard Spillner (chair), Department of Biological and Chemical Engineering, Aarhus University, Denmark

Main supervisor:
Associate Professor Menglin Chen, Department of Biological and Chemical Engineering, Aarhus University, Denmark

Co-supervisor:
Lars Groth Grunnet, PhD, Cell Delivery and Formulation, Novo Nordisk A/S, Denmark

Kåre Kryger Vøls, PhD, Cell Delivery and Formulation, Novo Nordisk A/S, Denmark

Camilla Ingvorsen, PhD, In Vivo Cell Efficacy and Histology Novo Nordisk A/S, Denmark

Louise Winkel, PhD, Global Search and Evaluation, Novo Nordisk A/S, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Technical Sciences/GSTS, Jens Baggesens Vej 53, building 5221, 8200 Aarhus N.

 

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