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Studies of bovine κ-casein digestibility – contributions from genetic variation, glycosylation and sialylation

PhD defence, Monday 29 November 2021. Bulei Sheng

2021.11.29 | Helle Mitzi Thomsen Reichl

Bulei Sheng

During his PhD studies, Bulei Sheng investigated the in vitro digestibility of bovine κ-casein; the only casein that can be glycosylated. The glycosylated κ-casein, especially with glycans containing sialic acid, is essential to keep the structure and stability of casein micelle. Bulei Sheng studied how genetic variations and glycosylation pattern, including varying glycosylation degree and sialylation, affects the digestibility and peptides release of skimmed milk and purified κ-casein.

The new research findings provide a molecular basis for understanding the contribution of heterogeneity in bovine milk proteins to the digestion pattern of milk and milk proteins, which could be applied to produce the dairy products with enhanced digestibility.

The PhD study was completed at Department of Food Science, Faculty of Technical Sciences, Aarhus University, Denmark.

This summary was prepared by the PhD student.

Time: Monday, 29. November 2021 at 13:00
Place: Building 5910, room 214, Department of Food Science, Aarhus University, Agro Food Park 48, 8200 Aarhus N.
Title of PhD thesis: INFLUENCE OF Κ-CASEIN HETEROGENEITY ON ITS IN VITRO GASTROINTESTINAL DIGESTION

Contact information: Bulei Sheng, e-mail: bulei@food.au.dk, tel.: +45 50327631

Members of the assessment committee:

Professor Isidra Recio, Institute of Food Science Research, CIAL, Spain

Associate professor Duc Ninh Nguyen, Section of Comparative Pediatrics and Nutrition, University of Copenhagen, Denmark

Professor Carl-Otto Ottosen (chairman), Department of Food Science, Aarhus University, Denmark

Main supervisor:
Professor Lotte B. Larsen, Department of Food Science, Aarhus University, Denmark

Co-supervisor:
Associate professor Nina A. Poulsen, Department of Food Science, Aarhus University, Denmark

Assistant professor Søren D. Nielsen, Department of Food Science, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English


The defence is public.
The PhD thesis is available for reading at the Graduate School of Technical Sciences/GSTS,

Katrinebjergvej 89F, building 5132, 8200 Aarhus N.

PhD defence
17427 / i43