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Chemical Hydride Transfer for Flavin Dependent Monooxygenases of Two-Component Systems – A Case Study of a Bacterial Baeyer-Villiger Monooxygenase

PhD defence, Wednesday 06 October 2021. Robert Röllig.

2021.10.06 | Sunitha Satkunam

Robert Röllig

During his PhD studies, Robert Röllig researched the replacement of cofactors for flavoproteins. Equipped with the power of flavins these biomolecules can catalyze many important reactions, such as oxidations, or in particular single oxygen insertions. This requires the flavin to be in its fully reduced state for which it needs to get two electrons. Robert Röllig investigated various non-natural methods to activate the flavin and therefore reveal the full catalytic potential of the flavoprotein cheaply and sustainably.

The new research findings contribute to the understanding of natural enzymatic two-component systems and potentially provides platform technologies for the application of many (flavo)protein in biocatalysis.

The PhD study was completed at Institut des Sciences Moléculaires de Marseille, Aix-Marseille University, and Biocatalysis and Bioprocessing, Faculty of Technical Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Wednesday, 06 October 2021 at 9:00 am
Place: St, Jerome Campus, Aix-Marseille University,13013 Marseille, France
The PhD defence will also be held online. To receive a link to the event, please send an e-mail to Dr Véronique Alphand,  v.alphand@univ-amu.fr or Prof. Dr Selin Kara, selin.kara@bce.au.dk
Title of PhD thesis: Chemical Hydride Transfer for Flavin Dependent Monooxygenases of Two-Component Systems
Contact information: Robert Röllig, e-mail: roellig@bce.au.dk
Members of the assessment committee:
Professor Willem J. H. van Berkel, Department of Agrotechnology and Food Sciences, Wageningen University and Research, The Netherlands
Professor Jan Deska, Department of Chemistry & Materials Science, Aalto University, Finland
Associate Professor Thomas W. Seviour, Department of Biological and Chemical Engineering, Aarhus University, Denmark
CNRS Research Director Thierry Tron, Institut des Sciences Moléculaires de Marseille, Aix-Marseille Université, France
Main supervisor:
CNRS Research Director Véronique Alphand, Institut des Sciences Moléculaires de Marseille, Aix-Marseille Université, France
Co-supervisor:
Professor Selin Kara, Department of Biological and Chemical Engineering, Aarhus University, Denmark
Language: The PhD dissertation will be defended in English

The defence is public.

Due to the coronavirus situation, the PhD thesis will not be available for reading at the offices of the PhD administration. Instead, interested parties may send an e-mail to gradschool.tech@au.dk to receive a digital copy of the PhD thesis. Please note, it may in certain cases be necessary to make an individual arrangement to read the PhD thesis.

PhD defence
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